Bosses from the world's two biggest plane makers have called on the US government to delay the rollout of new 5G phone services, BBC reported.
In a letter, top executives at Boeing and Airbus warned that the technology could have "an enormous negative impact on the aviation industry".
Concerns have previously been raised that C-Band spectrum 5G wireless could interfere with aircraft electronics, the report said.
US telecoms giants AT&T and Verizon are due to deploy 5G services on January 5.
"5G interference could adversely affect the ability of aircraft to safely operate," said the bosses of Boeing and Airbus Americas, Dave Calhoun and Jeffrey Knittel, in a joint letter to US Transportation Secretary Pete Buttigieg.
The letter cited research by trade group Airlines for America which found that if the Federal Aviation Administration's (FAA) 5G rules had been in effect in 2019, about 345,000 passenger flights and 5,400 cargo flights would have faced delays, diversions or cancellations.
The aviation industry and the US Federal Aviation Administration (FAA) have raised concerns about potential interference of 5G with sensitive aircraft equipment like radio altitude meters, the report added.
"Airbus and Boeing have been working with other aviation industry stakeholders in the US to understand potential 5G interference with radio altimeters," Airbus said in a statement.
This month, the FAA issued airworthiness directives warning 5G interference could result in flight diversions, saying it would provide more information before the January 5 rollout date.